Risk factors for the disseminated disease include extremes of age, diagnosis of AIDS, hematologic malignancy, history of transplantation, treatment with immunosuppressive agents, and congenital T-cell deficiencies. Patients who develop the progressive, disseminated form of histoplasmosis generally have an underlying condition impairing their ability to defend against these intracellular pathogens. In immunocompetent patients, these defense mechanisms are usually sufficient to control the infection. Once host cellular immunity to Histoplasma develops, the macrophages become activated to kill the organism. The yeast forms are then phagocytized by macrophages, which assist in spreading the organism to various parts of the body. Once inhaled by the susceptible host, the spores transform into budding yeast in warmer climates. In the environment, Histoplasma capsulatum exists as a mold with hyphae, which produce spores that are aerosolized and dispersed. She died 4 days after entering hospice care. ![]() During a return admission for complications related to her cirrhosis, the patient and family eventually elected hospice and comfort measures. Because of the persistent-disseminated fungal infection, she was not an appropriate liver transplant candidate. Unfortunately, over the next few weeks, despite appropriate treatment, the patient’s cellulitis worsened, and further decompensation of her cirrhosis occurred. All other antibiotics were discontinued, and since adequate serum concentration was attained, treatment with itraconazole was continued.Īfter a monthlong hospital admission, the patient was finally discharged. Itraconazole was initiated with the recommendation to switch to amphotericin if therapeutic levels of serum itraconazole were not achieved. Approximately 3 weeks after the rash was first noted, the tissue biopsy revealed findings consistent with histoplasmosis. Her regimen was changed to daptomycin and meropenem when both her leukocytosis and skin lesion worsened. For the cellulitis, intravenous vancomycin was added for presumed bacterial infection. Per recommendations of the infectious disease physician, her spontaneous bacterial peritonitis was treated with intravenous piperacillin/tazobactam but was later switched to intravenous cefepime. Histopathology of rash revealing numerous fungal elements in the dermis and subcutis indicative of disseminated histoplasmosis. A skin lesion present on her medial right thigh, measuring approximately 8 cm x 11 cm, had an area of central necrosis with slight purulent drainage surrounded by firm skin without crepitus ( Figure 1). She had a distended abdomen, a positive fluid wave, and bilateral lower extremity edema. ![]() Physical examination revealed stigmata of cirrhosis including scleral icterus and spider angiomata. On admission, she was noted to have mild tachypnea with a respiratory rate of 18. The patient was a Dallas County resident and had no history of recent travel, gardening, insect bites, unusual food consumption, or known sick contacts. ![]() Several days after admission, she developed a rash on the medial aspect of her right thigh. ![]() A 66-year-old Caucasian woman with a past medical history of type II diabetes mellitus and cirrhosis secondary to hemochromatosis presented with symptoms of decompensation including dyspnea, worsening ascites, and lower extremity edema.
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Apple’s senior vice president of worldwide Marketing, Greg Joswiak, describes these videos as “magical.” Although Apple, like most companies, can tend towards hyperbole, I’d say there is something really extraordinary about these videos, which I saw in a demonstration of the Vision Pro some months ago. In a Newsroom post, Apple specifies how the two latest Pro handsets are now capable of recording spatial videos, describing it as “a groundbreaking new capability that helps users capture life’s precious moments” and watch them back on the Apple Vision Pro when it’s released next year. Alongside the release of the update, Apple has set out lots more details about spatial video capture on the iPhone 15 Pro and iPhone 15 Pro Max. With big new features like Journal and so many smaller details, this is a big update.ĭecember 12 update. MORE FROM FORBES Apple iPhone iOS 17 NameDrop Causes Security Panic: Should You Be Worried? By David Phelanĭefault notifications sounds can be customized to a greater degree-something previously restricted to texts, mail and calendar alerts. There’s also Qi2 charger support for the iPhone 13 and iPhone 14, which haven’t had it until now. Similar to NameDrop (which is entirely secure, despite the furor that arose last week about it), you can now share boarding passes or movie tickets just by bringing two iPhones together. Typing messages, or anything else, is updated so you can turn off predictions inline, although personally I love that feature. There are improvements to Messages, including body shape customization in your Memoji, stickers to add to messages as reactions, and security improvements to protect against spyware. ![]() You can now set it to Translate, making it easy to have conversations in foreign languages without even having to open an app. These videos will play back in 3D on the headset-I’ve seen these videos on the headset, and they look amazing-but just regular 2D on the iPhone.Īlso on the iPhone 15 Pro and Pro Max only, there’s a new shortcut for the Action button, which replaced the Mute/Ring slider of previous iPhones. With this update you can shoot spatial video on the iPhone 15 Pro and iPhone 15 Pro Max. Talking of integration, with this release Apple AAPL has added the capability to shoot video in a particular way that will integrate with Apple’s next big product category, the Apple Vision Pro headset. It’s designed to help improve your wellbeing and is stunningly integrated into the iPhone, all securely encrypted to help your private entries stay for your eyes only. Chief among these is the new Journal app, which helps you write about the stuff that’s happening to you. Unlike the last couple of updates, which were all about bug fixes and security measures, iOS 17.2 has lots of new features as well as the customary bug-squishing effects. See the list of geographic exceptions for more detail on these. In some cases, the geographies where cases are reported do not map to standard county boundaries. A smaller file with only the most recent 30 days of data is also available in the us-counties-recent.csv file. ( Raw CSV file here.)īecause this file has grown too large, data for 20 are in separate files. territories and the District of Columbia, can be found in the us.csv file. The daily number of cases and deaths nationwide, including states, U.S. State and county files contain FIPS codes, a standard geographic identifier, to make it easier for an analyst to combine this data with other data sets like a map file or population data.ĭownload all the data or clone this repository by clicking the green "Clone or download" button above. If a county is not listed for a date, then there were zero reported confirmed cases and deaths. We do our best to revise earlier entries in the data when we receive new information. Please read here for a full discussion of this issue. Not all geographies are reporting probable cases and yet others are providing confirmed and probable as a single total. Our counts include both laboratory confirmed and probable cases using criteria that were developed by states and the federal government. ![]() The historical and live data are released in three files, one for each of these geographic levels: U.S., states and counties.Įach row of data reports the cumulative number of coronavirus cases and deaths based on our best reporting up to the moment we publish an update. The live data files are in the live/ directory.Ī key difference between the historical and live files is that the numbers in the historical files are the final counts at the end of each day, while the live files have figures that may be a partial count released during the day but cannot necessarily be considered the final, end-of-day tally. The historical data files are at the top level of the directory and contain data up to, but not including the current day. We are providing two sets of data with cumulative counts of coronavirus cases and deaths: one with our most current numbers for each geography and another with historical data showing the tally for each day for each geography. For answers to common questions, see our ( ) Live and Historical Data ![]() We will publish regular updates to the data in this repository. We have used this data to power our maps and reporting tracking the outbreak, and it is now being made available to the public in response to requests from researchers, scientists and government officials who would like access to the data to better understand the outbreak. Because of the widespread shortage of testing, however, the data is necessarily limited in the picture it presents of the outbreak. 21, 2020, The Times has tracked cases of coronavirus in real time as they were identified after testing. Since the first reported coronavirus case in Washington State on Jan. We are compiling this time series data from state and local governments and health departments in an attempt to provide a complete record of the ongoing outbreak. ![]() The New York Times is releasing a series of data files with cumulative counts of coronavirus cases in the United States, at the state and county level, over time.
"It may not seem like direct lobbying, but it is potentially indirect lobbying, depending on where the conversation goes. And that means that those that have pavilions might be able to invite certain governments to come and have a conversation," Dixson-Declève says. "Some are actually given easier access than others because they can pay for it. The number of lobbyists who attend the events has soared, she says, and civil society groups struggle to afford the cost of reserving pavilion space in the COP conference hall. The problem, Dixson-Declève told NPR, is combining international negotiations with a trade show. The summits have become a circus, "with the petrostates as the ringmasters" and everyone else as "the clowns," Sandrine Dixson-Declève wrote last year, as co-president of The Club of Rome, a nonprofit in Switzerland that works on climate change. Last year's COP27 meeting in Egypt ended with a watered-down agreement that left out language calling for a phaseout of all fossil fuels - the biggest driver of global warming. These meetings have been happening for 30 years, and it feels like climate change is only getting worse. And while it's still possible to stay below 2 degrees of warming - and every tenth of a degree of warming the world avoids will save lives - scientists warn that the 1.5 degree target is slipping away. analysis released this month found that global greenhouse gas emissions are still rising, and the planet is on track for at least 2.5 degrees Celsius of warming by the end of the century. This year, world leaders are required to review humanity's collective progress toward that goal. The goal is to limit global warming to well below 2 degrees Celsius compared to temperatures in the late 1800s, and ideally no more than 1.5 degrees Celsius. The Paris Agreement requires virtually every country on Earth to pledge how much they'll cut planet-warming pollution and update those plans every few years. This is the 28th Conference of the Parties, so it's called COP28.Īt the end of the 2015 COP meeting, world leaders signed the landmark Paris climate agreement. ![]() In U.N.-speak, the climate meeting is called the Conference of the Parties, or COP. This meeting happens every year and is arranged by the branch of the United Nations that handles global negotiations about climate change. Why is this meeting happening and what is it supposed to achieve? Here's what you need to know about what's at stake and what to expect. Meanwhile, a fight is brewing over whether the countries most responsible for causing climate change will follow through on promises to help the most vulnerable countries foot the bill for adapting to a hotter world. And while it's still possible for humans to avoid catastrophic climate change effects - such as mass extinctions and runaway sea level rise by the end of this century - it is only possible if greenhouse gas pollution falls dramatically and immediately, scientists warn. Extreme weather is killing people around the world. The meeting comes at the close of the hottest year ever recorded on Earth. ![]() Gatorade No Sugar is no different.Īvailable in a convenient 600mL sports drink bottle to help replenish and hydrate your body on-the-go. With a legacy over 50 years in the making, its the most scientifically researched and game-tested way to replace electrolytes lost in sweat. Gatorade is the Number 1 sports rehydration drink on the planet scientifically formulated to help refuel to support the demands you put on your body, which is why it's trusted by some of the world's best athletes. Ingredients Water, Citric Acid, Natural Flavor, Sodium Citrate, Salt, Monopotassium. During training and exercise, you burn off vital energy needed to continue competing with the best. 2,000 calories a day is used for general nutrition advice. The Ice Punch flavor from Gatorade is yet another refreshing sports drink that will boost your body with energy from electrolytes and minerals. ![]() Losses in fluids and electrolytes can negatively impact performance. Next on the list is a flavor that might not be readily available at your local store, but it is available on Amazon for you to order. You lose a whole lot more than water when you sweat. For current information, refer to packaging on store shelves. Gatorade No Sugar contains the essential electrolytes to help replace what’s lost in sweat and fuel you to perform at your best, all with zero carbs and minimal calories to compliment your nutritional efforts. Product formulation, packaging and promotions may change. For those times when you don’t need the carbs, Gatorade No Sugar offers flexibility, allowing you to personalise your nutrition to fit your current needs. Water, Sugar, Dextrose, Citric Acid, Natural Flavor, Salt, Sodium Citrate, Monopotassium Phosphate, Modified Food Starch, Glycerol Ester Of Rosin. Gatorade No Sugar Glacier Freeze is the high performance electrolyte sports drink which provides essential electrolytes lost in sweat, without the sugar. It is a great quick fix to something Apple still has not solved.īut dig a little deeper and it has features fit for power users. Click the menu bar (or simply hover your mouse over it) and they reappear. Get Bartender, though, and that becomes a thing of the past.Īt its simplest, Bartender lets you hide as many icons as you want from view. Unlike the Windows taskbar, there is no built-in way to hide this disarray, or even a way to bring a little order to chaos. The more you use your Mac, the more your menu bar gets filled up with icons. It is a simple solution to a persistent MacOS bugbear. ![]() The apps are context-sensitive (it won’t suggest you open a photo in TextEdit, for example), and you can even run scripts directly from the menu. It lets you add apps to the right-click menu, giving you quick options for opening files. We have previously praised this excellent app, and it is easy to see why. Unless, that is, you use Service Station. Changing the default app you use to open files is a long-winded and tedious affair, and its app suggestions are often completely wide of the mark. It might not seem like much, but the right-click menu in MacOS is a real pain. Service Station (Free with in-app purchases) Service Station gives a lot more control over what you see on the context menu Image used with permission by copyright holder ![]() It is perfect for quick interactions, then once you are done, it slides back out of your way. At your command, it briefly slides a small app window on top of whatever it is you are working on - for instance, you could be typing an email - then use Slidepad to bring across a Slack window to reply to a colleague’s message. This app brings the iPad’s Slide Over feature to the Mac. But regardless of what Apple does, you can bring the two systems a little closer together with a nifty app called Slidepad. Slidepad ($13 with free trial) Image used with permission by copyright holderĮvery year, people continuously bring up the idea that Apple will merge MacOS and iOS (spoiler: It’s not going to happen). Apple may try to keep its Macs pretty locked down, but BetterTouchTool proves things do not have to stay that way. You can customize Magic Mouse controls, keyboard shortcuts, and even the Touch Bar, chopping and changing them in whatever way you want. ![]() You can customize any gesture on your Magic Trackpad or create your own, giving you the ability to really make your Mac your own.īut it does not just work with the Magic Trackpad. Where Swish is quick and simple, BetterTouchTool gives you the power to tune things exactly the way you want them. Swish is not the only great gesture utility on MacOS - BetterTouchTool is another brilliant app that overhauls your trackpad gestures. BetterTouchTool ($8.50 with free trial) Image used with permission by copyright holder It integrates so well into the MacOS experience that it feels like a native Mac feature, it’s that natural. You can snap windows into all manner of formations and even move windows across desktop spaces. Once you get the hang of it, Swish reveals itself to be much more powerful than it first seems. How macOS Sonoma could fix widgets - or make them even worse 7 key settings in macOS Sonoma you should change right nowĪll the best macOS Sonoma tips and tricks you need to know ![]() When a new listener subscribes to the Stream, the cached values will be emitted to the listener. ReplaySubject - A broadcast StreamController that caches the added values.Furthermore, you can synchronously read the last emitted value. When a new listener subscribes to the Stream, the latest value or error will be emitted to the listener. BehaviorSubject - A broadcast StreamController that caches the latest added value or error.RxDart offers two additional StreamControllers with additional capabilities, known as Subjects: Example omIterable()ĭart provides the StreamController class to create and manage a Stream. They convert a source Stream into a new Stream with additional capabilities, such as buffering or throttling events. The extension methods provided by RxDart can be used on any Stream. ![]() If you're looking for an Interval equivalent, check out Dart's Stream.periodic for similar behavior.CombineLatestStream (combine2, combine3.Example: final mergedStream = Rx.merge(). ![]() Under the hood, these factories call the corresponding Stream constructor. Using static factories from the Rx class, which are useful for discovering which types of Streams are provided by RxDart.Example: final mergedStream = MergeStream(). ![]()
![]() ![]() Joining Database Tables on Non-Foreign Key Fields.Navicat 16.3 Adds Support for Redis Cluster.What Sets Redis Apart from Other Databases.Understanding Navicat Connection Profiles.Choosing Between Redis and a Traditional Relational Database.Measuring Query Execution Time in Relational Databases.Why not download it and try it out for yourself? Here's a free 14 day trial! In today's blog, we got a preview of Navicat Premium 15's most top new features and improvements. ![]() Whereas previous versions of Navicat Modeler required Wine to run on Linux systems, version 15 is a true Linux application, so users can now enjoy a UI that is more in line with other Linux apps! Conclusion You'll find it on the General options screen. In contrast to the mostly whites of Windows themes, dark theme displays dark surfaces across the majority of the UI. Navicat 15 gives you the choice between the traditional Windows (light) theme and the new Dark Theme. For that reason, dark themes have become increasing prevalent in recent years. Dark ModeĪ lot of people find that bright themes, including the default white of Windows, make their eyes tired after many hours in front of the screen. Once you're ready, you can choose and reorder your synchronization scripts to update the destination database. It shows a side-by-side DDL comparison that makes locating all the object differences a snap. ![]() The updated Data Modeler introduces a new mechanism for Database Synchronization, starting with a more intuitive way to visually compare and identify the differences between the model and database. Navicat 15 includes the new and improved Data Modeler 3.0. In addition to the new UI, Navicat 15 now supports subqueries to further fine-tune your query results. Moreover, the resulting SQL statement is displayed in the right pane so that you can make modifications, should you make any syntax errors. Whereas version 12 showed all of the query syntax in one statement, version 15 breaks it down into clauses: Select, From, Where, Group By, Having, Order By, and Limit. Navicat 15 introduces a whole new approach to writing SQL via the new Query Builder. Perhaps even more importantly, Navicat 15's Data Transfer is designed to quickly migrate massive amounts of data - quick enough to accomplish the most complex transfers faster than ever before. You can also limit the number of rows to transfer using custom filters. For instance, you can choose specific fields to transfer and even change the field names. The new design includes an intuitive interface for customizing the fields and specifying the number of rows you wish to transfer. Today, we'll be taking a look at other improvements, including Data Transfer, Query Builder, Data Modeler and more!Īlthough Navicat already supports the transfer of database objects from one database and/or schema to another, or to an sql file, version 15 brings a whole new experience along with a number of new functions to the Data Transfer utility. In the last blog, we explored the Data Visualization feature. In addition to over 100 enhancements, Navicat includes several new features to give you more ways that ever to build, manage, and maintain your databases. It comes packed with numerous improvements and features to address all of your database development and administration needs. Perhaps you've heard that version 15 of Navicat's flagship product, Navicat Premium, was officially released on November 25th. Navicat Premium 15 - the Most Powerful Yet! | Navicat Blog by Robert Gravelle ![]()
The following topics contain information about designing, planning, deploying, and maintaining AppLocker policies: Resources to support the deployment process The following diagram shows the main points in the design, planning, and deployment process for AppLocker. With an accurate inventory, you can create rules and set enforcement criteria that will allow the organization to use the required applications and allow the IT department to manage a controlled set of applications. The key to the process is taking an accurate inventory of your organization's applications, which requires investigation of all the targeted business groups. To successfully deploy AppLocker policies, you need to identify your application control objectives and construct the policies for those objectives. ![]() This planning and deployment topic for the IT professional describes the process for using AppLocker when deploying application control policies. Learn more about the Windows Defender Application Control feature availability. An example of this type of software is the Advanced Group Policy Management feature from the Microsoft Desktop Optimization Pack.Some capabilities of Windows Defender Application Control are only available on specific Windows versions. To ensure version control when modifying an AppLocker policy, use Group Policy management software that allows you to create versions of GPOs. However, you can't specify a version for the AppLocker policy by importing more rules. You can edit an AppLocker policy by adding, changing, or removing rules. For the procedure to alter the enforcement setting, see Configure an AppLocker policy for audit only. For information about the enforcement setting, see Understand AppLocker Enforcement Settings. By default, if enforcement isn't configured and rules are present in a rule collection, those rules are enforced. AppLocker divides the rules into collections: executable files, Windows Installer files, packaged apps, scripts, and DLL files. Rule enforcement is applied only to a collection of rules, not to individual rules. For the procedures to do this task, see Export an AppLocker policy to an XML file and Import an AppLocker policy from another computer. For local AppLocker policies, you can update the rule or rules by using the Local Security policy snap-in (secpol.msc) on your AppLocker reference or test PC. For the procedure to do these tasks, see Export an AppLocker policy from a GPO and Import an AppLocker policy into a GPO. ![]() Using Group Policy, you can export the policy from the Group Policy Object (GPO) and then update the rule or rules by using AppLocker on your AppLocker reference or test PC. Updating an AppLocker policy that is currently enforced in your production environment can have unintended results. These procedures assume that you have already deployed AppLocker policies with the enforcement set to Audit only, and you have been collecting data through the AppLocker event logs and other channels to determine what effect these policies have on your environment and the policy's adherence to your application control design.įor info about the AppLocker policy enforcement setting, see Understand AppLocker enforcement settings.įor info about how to plan an AppLocker policy deployment, see AppLocker Design Guide. This topic for IT professionals describes the steps to deploy AppLocker policies by using the enforcement setting method. Some capabilities of Windows Defender Application Control are only available on specific Windows versions. |
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